Moore has spent more time in and out of rehab than most of the people on this list. She had pill, alcohol, and drug dependencies throughout her life. Sadly, her family has a long history of substance abuse and this affected her. Her relationship with actor Ashton Kutcher also caused her to relapse.
This is because he reportedly didn’t take her alcoholism seriously. He allegedly said that he didn’t know if it was a real thing and suggested everything was fine in moderation. Moore fell into another cataclysm but luckily recovered before it was too late (via Cosmopolitan).