Like Farrell above, there was a time when Zeta-Jones was one of Hollywood’s hottest stars. The Welsh actress starred in The Mask of Zorro, Wednesday, and many other franchises. However, her bipolar disorder affected her quality of life. From 2011 she was in and out of rehab as she dealt with her struggles.
Remember, this was around the time that her husband, Michael Douglas, was also struggling with tongue cancer. This placed a lot of stress on Zeta-Jones too because she cared about her husband. In the end, it was too much for her to handle by herself but she confronted her demons (via The Guardian).